SNAI1, SNAI2, SNAI3 (AA 188-264) Antikörper

Produktnummer ABIN685597

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) und WB. Er zeigt eine Reaktivität gegenüber Human und Kaninchen und wurde in 1 Publikation erwähnt.

Kurzübersicht für SNAI1, SNAI2, SNAI3 (AA 188-264) Antikörper (ABIN685597)

Target: SNAI1, SNAI2, SNAI3

Reaktivität: Human, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 188-264

Kreuzreaktivität: Human, Kaninchen

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Snail

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen

Takahashi, Akamatsu, Yagami, Hasegawa, Ohgo, Abe, Iwata, Arima, Mizutani, Nakata, Matsunaga: "Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea." in: The Journal of dermatology, Vol. 40, Issue 9, pp. 720-5, (2013) (PubMed).

Antigendetails

Target: SNAI1, SNAI2, SNAI3

Hintergrund:

Synonyms: dJ710H13.1, Protein sna, Protein snail homolog, SLUGH2, SNA, Sna protein, SNAH, SNAI1, Snail homolog 1 Drosophila, Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, dJ710H13.1, SNAIL, SNAIL1, Protein sna, SLUG, WS2D, SLUGH, SLUGH1, SNAIL2, SMUC, SNAIL3, ZNF293, Zfp293

Background: The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression.

Molekulargewicht: 29kDa

Gen-ID: 6615, 6591, 333929

UniProt: Q02085, P97469, Q9QY31